Monoclonal gammopathy of uncertain significance (MGUS)

#hemato #nonrad

Part of plasma cell proliferative disorders

Precursor to multiple myeloma

Abnormal M-protein detected (serum or urine)
Bone marrow: <10% clonal plasma cells
No CRAB features (no hypercalcemia, renal dysfunction, anemia, or bone lesions)
Risk of progression to MM: ~1% per year