POEMS syndrome

Plasma cell dyscrasia with

• Polyneuropathy (sensorimotor)
• Organomegaly
  • Hepatosplenomegaly
  • Lymphadenopathy
• Endocrinopathy
  • Diabetes meliitus
  • Amenorrhea
  • Gynecomastia
  • Impotence
  • Hypothyroidism
• M protein
• Skin changes
  • Skin thickening
  • Hyperpigmentation
  • Papilledema
  • Episodes of anasarca

Imaging:

• peculiar pattern of bone proliferation consists of fluffy, spiculated, hyperostotic areas.
• predilection for the vertebral column and pelvis.